The series follows James St. Patrick, nicknamed "Ghost", owner of a popular New York City nightclub. In addition, he is a major player in one of the city's biggest illegal drug networks. He struggles to balance these two lives, and the balance topples when he realizes he wants to leave the drug ring in order to support his legitimate business.

故事以纪录片的方式展开，一队纪录片摄制组采访了一位深居简出的疯人画家，但之后他们发现这位疯子似乎人间蒸发了，而他们这部纪录片成为解谜的关键。而片尾疯子那句“我们到底谁才是疯子？”令人颇感神秘。